An important event in the unfolded protein response (UPR) is activation of the endoplasmic reticulum (ER) kinase PERK.The PERK signalling branch initially mediates a prosurvival response, which progresses to a proapoptotic response upon prolonged ER stress.However, the molecular mechanisms of PERK-mediated cell death are not well understood.Here we
In long-distance gas transmission pipelines, there are many booster compressor stations consisting of parallel compressors that provide pressure for the delivery of natural gas.So, it is economically important to optimize the operation of the booster compressor station.The booster compressor station optimization problem is a typical mixed integer n
The unstable isomeric compounds 5-hydroxy-7-prop-2-en-(E)-ylidene-7,7adihydro-2H-cyclopenta[b]pyran-6-one (1) and 5-hydroxy-7-prop-2-en-(Z)-ylidene-7,7adihydro-2H-cyclopenta[b]pyran-6-one (2), previously described as antimicrobialmetabolites from the sponge Ulosa sp., were isolated and identified as major componentsof the ascidian Diplosoma virens.
The principal objective of this investigation is to assess the hydrodynamic characteristics and the exciting forces induced by waves acting upon a shallowly submerged spheroid.This study focuses on an arbitrarily shaped spheroid body with a vertical axis, fully immersed beneath the free surface within waters of finite depth.The methodology outlined
Background Human immunodeficiency virus (HIV) infected individuals are prone to opportunistic infections (OIs) due to HIV mediated immune suppression.When opportunistic infections occur in the form of relapse or reinfection, it is said to be reoccurrence.This study was aimed to assess Incidence and predictors of reoccurrence of opportunistic infect